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Immunohistochemical Detection of Her2/neu Protein p185Her2

Immunohistochemical Detection of Her2/neu Protein p185Her2 in Feline Mammary Carcinoma


<b>Background</b>


A lot of work has been done recently to establish a Human Genome Model, a genetic map, physical map and comparative DNA sequence of human chromosomes. This work with the Human Genome Model cannot be achieved without a small part upon the parallel implementation of gene mapping projects in other species. One of these other species which has been associated with the human recently has been the feline (1). With exception to the primates, of the nonprimate mammalian species with developing comparative gene maps, the feline gene map (Felis Cat) displays the highest level of syntenic conservation with that of the humans gene map. The comparison of the human and feline map has shown many similarities between the human and feline, one of the how to a heart most important similarities being the analogous relationship between felines and human diseases (2).


<b>Her2/neu Gene</b>


The human epidermal growth factor receptor 2 (Her2)/neu proto-oncogene, sometimes seen referred to as c-erbB2, encodes a 185kDa transmembrane tyrosine kinase receptor protein with homology to the epidermal growth factor (egfr) receptor (3).


The Her2/neu gene has an important role in normal cell growth and differentiation (6,7). Templates? The egfr family of receptors (including the Her2/neu gene) is involved in cell-to-cell and cell-to-stroma communication primarily through a process known as signal transduction, in which external growth factors, or ligands, affect the transcription of various genes by phosphorylating or dephosphorylating a series of transmembrane proteins and intracellular signaling intermediates, many of which possess enzymatic activity (4). Receptor activation requires three variables, a ligand, a receptor and a dimerization partner (5). After a ligand binds to a heart broken, a receptor, that receptor must interact with another receptor of identical or related structure in a process known as dimerization in order to trigger phosphorylation and activate signaling cascades (picture 2b). The...

Hobbes' Argument for a Sovereign State

             Thomas Hobbes is recognized to be a great advocate of absolute authority within a state. The essay that follows will illuminate Hobbs' reasons (premises) for the elimination of distributed authority in his political philosophy as in The Leviathan. Hobbes argues that an ailing commonwealth has many subsidizing factors. One of which would naturally be if the a heart broken song, sovereign does not enjoy ultimate power over his public. Hobbs articulates his concern that this may lead to social disorder. Furthermore, he understands that revolting is dispatched to the kin of the people and equates it to an illness or a birth defect. Alternatively, individuals should be prohibited to assess, for themselves, what deeds are good or evil. Hobbes suggests that civil law should dictate what actions are conventional and force these rules upon the masses. When the populaces deliberate and then disregard the commonwealth the system will tumble. The commonwealth, tainted by yet another illness, could not operate when entities consider their integrity superior above that public duty requires. Again man should not be tolerated to decide for himself what is acceptable behavior. Hobbes defends his statement by stating that a man's conscience and judgement are identical. Within the commonwealth man is subject to the public conscience that should be conformed to without any distraction of divided opinion.
             In a commonwealth the essay toefl, sovereign cannot be subjected to his own laws as he is to the laws of nature. He could not be accountable to himself and thus not to the commonwealth's regulations. The sovereign could likewise not possibly be held accountable by another, more powerful sovereign and write a heart song so that sovereign by yet another, until eternity. It would not be possible for a commonwealth to perform if man has a sense of politeness concerning his own commodities. His will consequently eradicate the power of the sovereign's rule. Each individual has the right to his own possessio

Ecstasy

             Ecstasy (also commonly known as MDMA, X, E, XTC, or Adam) on
             the street, is a semi-synthetic psychoactive drug with amphetamine-like
             and hallucinogenic properties. It is classified as both a stimulant and a
             hallucinogen. Ecstasy abuse in the United States, and the buying and
             selling of it to the United States, are significantly on broken song, the rise posing
             serious concerns. Ecstasy may not seem very dangerous, but it has been
             linked to serious brain damage or in some cases, has even been blamed
             Ecstasy has many effects on the user that takes it. Some ecstasy
             users say that the drug lowers your inhibitions, breaks down barriers
             between friends, enhances sensations, feelings of love, and affection.
             It also puts the user in a relaxed, euphoric state. This all may sound
             good, but actually there are many bad effects too. Ecstasy can cause
             hallucinations, chills, involuntary teeth clenching, muscle cramping,
             blurred vision, and an increase in body temperature, heart rate, and
             blood pressure. Some long-term effects of the drug also include severe
             or permanent brain damage, chronic depression, anxiety, or memory
             loss. There are also withdrawal symptoms which include hyperactivity,
             hyperexcitibility, tremors, convulsions, or death.
             Ecstasy has no proven medical use and is mostly a street and
             designer drug. It is usually taken by argumentative essay samples pill, but in some cases can be
             sniffed or taken through an IV. This drug is VERY popular at "raves ? (all
             night dance parties featuring "house ? music) because of its
             hyperactiveness and its effect of keeping the user more awake and
             "alive. ? There are many different costs for the drug, but in most cases
             it ranges in price from $10-30 a dose. There are very alarming
             statistics involving ecstasy. In the 1998 survey of Americans over 12
             years of age, over 3 million Americans have used the drug at broken song, least once
             in their lifetime. Write Broken Song? Another survey tak

Economic Price Bubbles

             What do economists mean by the term “asset price bubble”? Are efficient markets prone to asset price bubbles? What methods have economists and real estate analysts used to determine the presence of housing bubbles and what are the shortcomings of those methods?
             It would seem that economists define the term “asset price bubble” in a number of ways to varying degrees of success. Evanoff et al. define a bubble existing “when the write broken market price of an asset exceeds its price determined by fundamental factors by a significant amount for a prolonged period”.1 This definition although seemingly certain is very vague in it's nature. It begs the questions, how long is a prolonged period, by how much is the asset's fundamental value exceeded? In their defense however, in the summing up section of their paper it is stated, “we still do not have a definition of an asset bubble”. Schiller in his paper suggests, “Economists define a bubble as a rise in price that cannot be explained by fundamental factors influencing price.”2 The common term is the “fundamental factor” referenced in both definitions. Schiller goes on to say that the most common “nonfundamental” factor that drives price increases is a “belief that prices will rise in the future” suggesting that behavior is argumentative samples toefl, a key influence in the creation of asset price bubbles. How To A Heart Song! Himmelberg et al in particular reference the recent housing price bubble “as being driven by home buyers who are willing to pay inflated prices for houses today because they expect unrealistically high housing appreciation in the future.”3
             It can be argued that efficient markets are prone to asset price bubbles. If one prescribes to the school of thought of efficient market hypothesis, even as a hybrid with behaviorist ideology, the recent bubble surrounding housing prices and mortgage backed securities can be shown to be evidence that efficient markets can be susceptible to the prese

Hat

             He was probably the best friend I ever had. We went through everything together. He was there for me every time I needed him, through my parents divorce, and through almost every difficult time in my life since I was 13 years old. He was known as my Knicks hat. The New York Knick hat I got for Christmas when I was in write a heart song, 7th grade. That was the last Christmas I ever spent with my Dad, the last Christmas we ever spent as a family. For that Christmas break he informed my mom and I he was leaving for good. At the time, it saddened and disappointed me. Now however, almost six years later I am all the stronger. I have a deep appreciation for family and friends perhaps more than other kids that have not been through a divorce.
             (I need a better transition here, could you help me)I lost him once. My Mom and I took a ride in her car with the broken song top down. We were cruising down the highway when the joy ride took a turn for how to write a heart broken song the worst. My hat flew off my head and out onto the highway of speeding cars and monstrous trucks. Mom thought it was gone for good, but I would not let that happen. How To Write. I began my frantic search on the side of the highway and I could not believe my luck. There, safely on the shoulder of the road was my trusty old Knicks hat! We were reunited.
             My Mom hated that old smelly hat, but she understood its significance, just like she understands me. None of my friends understood its value. Certainly it was not the most beautiful hat, but it meant so much to me. My Mom was the only person who recognized its true meaning. She understood the security I felt with that hat. It was molded so perfectly to my head. How rare it is to get a perfectly fitted hat. The meaning of that bond to keep the past alive and also share the experiences that molded me into who I am today was simply signified in how to a heart, my Knicks hat. Faded and torn, pieces held together with duct tape, and stained from the sweat of my forehead it was the most bea

Exploratory Essay - The Effect of Divorce on Children

             Throughout human history, people have seemingly tied the love they had for each other through the legal binding called ‘marriage'. When two people come together for marriage, it is not typically on their mind to end the marriage in a harsh divorce, it is more times than not the exact opposite. While the true definition may vary, depending on where you are in the world and what religion one is recognized with, the base is the same, two people are together for what should be a lifetime. There are many different reasons why people may get wedded, in some countries and cultures, it is because they have to, or because the family makes an offer in which they are unable to refuse. For example, in India, China and even Japan, there are places where arranged marriages is a part of the culture. However, in a heart song, other cases, marriage may be the way to a better life, or the women was expecting. Whatever the reason is for getting married, the normal wedding liturgy includes the lines: “Till death does us part”, but what happens when the couple wants to end the marriage before death has the chance to do them part? Well, the once happily marriage couple can file for divorce.
             While marriage is the legal binding of two people, divorce is the legal separation, recognizing the end of the marriage. Just as there are numerous causes for marriage, there are also numerous for divorce. How To A Heart Song. Some explanations might include: marrying at an early age, less education and income, living together before marriage, a premarital pregnancy, no religious affiliation, coming from a divorced family, and feelings of insecurity. The list of reasons for getting a divorce goes on and on. (Williams, “Reasons for Divorce”). During the marriage, or before, they, typically speaking, have children. Unfortunately, these children can tragedy add to how to write a heart the motive for the once married couples attaining a divorced. Divorce might be a way out of the marriage, and could be for the best

Suicide

             In the Internet based text entitled "If you are thinking about suicide, read this first ? I aim to discover and analyse the how to techniques used to persuade the reader.
             The author, in the first paragraph of the text explains that she is not a professional, instead, a normal person who "knows what it is like to write a heart song be in pain. ? This colloquial, less removed approached may help the reader cope with what is happening to them and how they are feeling. The text on numerous occasions congratulates the reader for getting that far into the text, to build self-esteem and build confidence in the reader.
             "Well, it's been a few minutes and you're still with me. I'm really glad. ?
             The author is clever in the way she attempts to persuade, rather than making suicide a taboo, she lets the reader know that, although suicide is not an acceptable option, she understands how the reader feels. The author does however, plead with the reader to finish reading the text before making the life ending decision, she does this by putting herself into the readers' position, attempting to how to understand the misery that they are reading. The author has then bought herself enough time to attempt to dissuade the reader from suicide. The author attempts to use her writing as a place rather than a textual piece using phrases such as "I can assume that you are here because...ending your life. ?
             During the text there is a quote in much larger letters, which reads:
             "Suicide is not chosen; it happens when pain exceeds resources for coping with pain. ? This quote is emboldened and enlarged to
             attract attention to the fact that the reader is not at fault for feeling suicidal, and this is a very powerful and important quote.
             The author uses a friendly voice to get her message across she is sensitive to how the reader is feeling and says nothing that could possibly make t
            
            

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